Another obvious peril, it seems to me, would be exotericism, the gradual whittling down of the population communicated to. Defection doesn’t simply challenge readers, it alienates them. With every rule you choose to follow or not to follow you are either connecting or disconnecting yourself from certain populations of readers. Since humans have a hardwired appreciation of narrative conventionality, mucking with these norms is tantamount to turning your back on the greater human community, and appealing to those who happen to share your acquired tastes.
When I stand in front of crowds–even huge ones–my overriding desire is to argue and shock and unsettle. My whole life, I’ve had this perverse desire to prick bubbles wherever I go, and to make the babies blowing them cry-cry-cry.